Quantitative Evaluation of Antibiotic Prescribing in Dengue Patients: Application of the ATC/DDD Method at HKBP Hospital
Keywords:
Antibiotic Use, ATC/DDD Method, Dengue Fever, Drug Utilization, Rational PrescribingAbstract
Infectious diseases, including those caused by pathogenic bacteria, remain a major health concern worldwide. The widespread use of antibiotics in treating infectious diseases increases the risk of irrational prescribing, potentially leading to suboptimal therapeutic outcomes. This study aims to evaluate antibiotic utilization based on patient characteristics, antibiotic usage profiles, and the quantity of antibiotic consumption in Defined Daily Dose (DDD) units among hospitalized patients at HKBP General Hospital diagnosed with dengue fever. This was an observational, retrospective study using secondary data extracted from the Hospital Information System (SIRS) for the period of January to April 2024. Collected data included drug names, dosage forms and strengths, total quantities used, number of hospitalized patients per month, and duration of hospital stay. Data analysis employed the Anatomical Therapeutic Chemical (ATC)/DDD methodology and the Drug Utilization 90% (DU90%) approach. The findings showed that two types of antibiotics were prescribed for dengue fever patients during the study period, with an average total consumption of 280.07 DDD/100 patient-days. The most frequently used antibiotics were cefixime (66.70%) and cefotaxime (33.30%). Intravenous administration was the predominant route, and the majority of patients (85.71%) received antibiotic therapy for less than 3 days. These results highlight the need for continuous monitoring of antibiotic use to ensure rational prescribing practices in hospital settings
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